Protein that suppresses androgen receptors could improve prostate cancer diagnosis and treatment.

"With increased numbers of androgen receptors, prostate cancer can make use of the limited testosterone available after a diseased prostate gland is removed or after testosterone production is blocked by drug therapy. In fact, the increased number of androgen receptors may mutate so they can start feeding off other steroids or even growth factors, Dr. Daaka says.

These wily skills help explain why cancer returns despite initially promising treatment results.

"It is clear that signaling by the androgen receptor is paramount for not only the initiation but also the progression of the disease, including escape to a hormone-refractory disease," he says. Moves androgen receptors make to support cancer growth make it "unbeatable at this point," for some patients."

Perhaps I haven't been paying attention in recent months but it appears scientists are now saying that in times of low testosterone the human body is able to increase the numbers of androgen receptors in certain tissues so that the small amount of testosterone left has a greater effect.

I'm theorizing based on this new info that a period of very low testosterone directly following a cycle might actually help us in the long run by tricking the body into creating more androgen receptors. Hopefully these new receptors would be produced in muscle cells and not just unwelcome places like the prostate.

1 comment:

  1. interesting stuff... maybe "blast-cruise" cycles are the way forward then...

    AJ

    ReplyDelete