Depot testosterone injections in men with metabolic syndrome and hypogonadism led to improvements in several important components of their disease, including significant weight loss and reduced glucose dysregulation, a researcher said here.
Interim results from a randomized, placebo-controlled trial showed that men receiving the hormone injections lost more than 4 kg (9 lb) in the first 30 weeks of a planned three-year study versus almost no change with placebo (P<0.001), reported Farid Saad, PhD, of Bayer Schering in Berlin.
Although fasting plasma glucose levels did not change, insulin levels dropped significantly among participants in the active treatment group, mainly among those with abnormally high levels at baseline, Saad told attendees here at the World Congress on Controversies to Consensus in Diabetes, Obesity, and Hypertension.
There were also trends toward normalized levels of certain blood lipids, serum leptin, and inflammation markers.
Showing posts with label Testosterone undecanoate. Show all posts
Showing posts with label Testosterone undecanoate. Show all posts
US FDA approval of Nebido / Aveed ( long acting T injection ) delayed.
"In the complete response letter, the FDA has requested information from Endo to address the agency's concerns regarding very rare but serious adverse events, including post-injection anaphylactic reaction and pulmonary oil microembolism. The letter also specified that the proposed Risk Evaluation and Mitigation Strategy (REMS) is not sufficient."
Testosterone Treatment May Have Non-Sexual Benefits.
“Physicians are often reluctant to prescribe testosterone for conditions not related to sexual function,” said co-investigator Farid Saad, PhD, head of scientific affairs for Men's Healthcare at Bayer Schering Pharma in Berlin and an honorary professor in clinical research and endocrinology at Gulf Medical College, Ajman, United Arab Emirates. “However, our study shows that testosterone has a much wider therapeutic role than just for improving sexual desire and erectile function.”
This study sponsored by Schering shows male Testosterone replacement therapy using injectable Testosterone Undecanoate in a very positive light, other testosterone esters would of course have equal benefit but would require more frequent injections.
This study sponsored by Schering shows male Testosterone replacement therapy using injectable Testosterone Undecanoate in a very positive light, other testosterone esters would of course have equal benefit but would require more frequent injections.
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